RNAi Tools: Transformative Potential in Genetic Screening, Drug Development, and Precision Medicine Since its discovery in 1998, RNA interference (RNAi) has evolved from a basic research tool into a cornerstone technology driving multidimensional breakthroughs in life sciences. Its innovative applic … RNAi Tools: Transformative Potential in Genetic Screening, Drug Development, and Precision MedicineRead more
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Cross-Species Synthetic Biology and Breakthroughs in Modified RNA Technologies
Cross-Species Synthetic Biology and Breakthroughs in Modified RNA Technologies I. Core Drivers and Prospects of Cross-Species Synthetic Biology Cross-species synthetic biology aims to engineer diverse biological systems (microbes, plants, animals, or artificial cells) to integrate metabolic pathways … Cross-Species Synthetic Biology and Breakthroughs in Modified RNA TechnologiesRead more
Engineered Modified RNA and Its Biological Significance
Engineered Modified RNA and Its Biological Significance Core Technical Strategies for Modified RNA 1. Nucleobase Engineering Natural Modification Engineering: Incorporating naturally occurring modified nucleosides (e.g., N1-methyl-pseudouridine, pseudouridine) into mRNA vaccines reduces immunogenici … Engineered Modified RNA and Its Biological SignificanceRead more
GenoFus: Precision Detection of Gene Fusions in Lung Cancer and Targeted Therapy Decision-Making
GenoFus: Precision Detection of Gene Fusions in Lung Cancer and Targeted Therapy Decision-Making GenoFus is an integrated gene fusion detection system combining next-generation sequencing (NGS), artificial intelligence (AI), and multi-omics analysis, designed for precision lung cancer treatment. Bel … GenoFus: Precision Detection of Gene Fusions in Lung Cancer and Targeted Therapy Decision-MakingRead more
RNA Scan: Spatial Transcriptomics and Spatiotemporal RNA Dynamics Analysis
RNA-Scan: Spatial Transcriptomics and Spatiotemporal RNA Dynamics Analysis RNA localization and dynamics are central to cellular function regulation. Recent advances in spatial transcriptomics (ST) enable researchers to analyze RNA distribution and dynamics at subcellular to tissue scales. RNA-Scan, … RNA Scan: Spatial Transcriptomics and Spatiotemporal RNA Dynamics AnalysisRead more
Why Are RNA Primers Used Instead of DNA in DNA Replication?
Why Are RNA Primers Used Instead of DNA in DNA Replication? DNA replication is a fundamental molecular process, and the use of RNA primers over DNA primers involves intricate biochemical mechanisms and evolutionary logic. Below is a multi-dimensional analysis of this phenomenon: I. Functional Limita … Why Are RNA Primers Used Instead of DNA in DNA Replication?Read more
Core Types of RNA Therapy and Breakthroughs in Rare Disease Treatment
Core Types of RNA Therapy and Breakthroughs in Rare Disease Treatment RNA therapies precisely regulate disease by targeting various stages of gene expression. Below is an analysis of their core types, recent advancements in rare diseases, and future directions. I. Core Types of RNA Therapy Antisense … Core Types of RNA Therapy and Breakthroughs in Rare Disease TreatmentRead more
RNA Modifications: From Disease Mechanisms to Precision Medicine and Tumor Microenvironment
RNA Modifications: From Disease Mechanisms to Precision Medicine and Tumor Microenvironment RNA modifications—such as m6A, m5C, ac4C, and Ψ—dynamically regulate gene expression programs, serving as a nexus connecting disease pathogenesis, tumor microenvironment (TME) remodeling, and precision medici … RNA Modifications: From Disease Mechanisms to Precision Medicine and Tumor MicroenvironmentRead more