SynBio V: Engineering Viral Vectors for mRNA Vaccine Design and Production Integrating Viral Delivery Systems with Synthetic Biology Tools 1. Technological Foundations: Synthetic Biology Reengineering of Viral Vectors Viral vectors, as core mRNA delivery tools, require synthetic biology modification … SynBio V: Engineering Viral Vectors for mRNA Vaccine Design and ProductionRead more
mrna
Synthetic mRNA Applications in Vaccine Development and Gene Therapy
Synthetic mRNA Applications in Vaccine Development and Gene Therapy I. Vaccine Development Advancements Infectious Disease Prevention: • Demonstrated rapid response capability through COVID-19 vaccine success • Expanding applications include: RSV, influenza, and Zika virus candidates in clinical tri … Synthetic mRNA Applications in Vaccine Development and Gene TherapyRead more
Velo mRNA: Decoding Dynamic mRNA Patterns via RNA Velocity Theory
Velo mRNA: Decoding Dynamic mRNA Patterns via RNA Velocity Theory RNA velocity is a computational method that quantifies the relative abundance of unspliced and spliced mRNAs to reveal dynamic gene expression changes. By modeling transcriptional kinetics, it predicts future cellular states, enabling … Velo mRNA: Decoding Dynamic mRNA Patterns via RNA Velocity TheoryRead more
mRNA Velocity in Cancer: Advances in Transcription Rate Mutations and Therapeutic Prospects
mRNA Velocity in Cancer: Advances in Transcription Rate Mutations and Therapeutic Prospects mRNA velocity—defined as the elongation rate of RNA polymerase during transcription and the dynamic lifecycle of mRNA from synthesis to degradation—has emerged as a critical factor in cancer biology. Aberrant … mRNA Velocity in Cancer: Advances in Transcription Rate Mutations and Therapeutic ProspectsRead more
Comparative Analysis of mRNA Velocity and Traditional Single-Cell Transcriptomic Approaches
Comparative Analysis of mRNA Velocity and Traditional Single-Cell Transcriptomic Approaches RNA Velocity is a kinetic model that predicts future transcriptional states of single cells by analyzing the ratio of unspliced to spliced mRNA. Unlike traditional single-cell methods (e.g., pseudotime trajec … Comparative Analysis of mRNA Velocity and Traditional Single-Cell Transcriptomic ApproachesRead more
SynthmRNA vs. Natural mRNA: A Comparative Analysis
SynthmRNA vs. Natural mRNA: A Comparative Analysis 1. Definition and Basic Structure Natural mRNA: Transcribed from nuclear DNA, it carries genetic information for protein synthesis. Its structure includes a 5′ cap, 5′ untranslated region (UTR), open reading frame (ORF), 3′ UTR, an … SynthmRNA vs. Natural mRNA: A Comparative AnalysisRead more
mRNA Speed-mRNASpeed
mRNA Speed: A Concise Overview mRNA Speed (or mRNA Velocity) is an analytical technique in single-cell RNA sequencing (scRNA-seq) that quantifies dynamic changes in gene expression rates and predicts future directions of cellular state transitions. Below are its key components: 1. Definition and Pri … mRNA Speed-mRNASpeedRead more
mRNA Velocity-VelomRNA
1. Definition and Principle 2. Key Tools 3. Applications Field Use Case Cell Differentiation Predicts dynamic pathways of stem cells differentiating into neurons or immune cells. Cancer Research Tracks tumor cell evolution (e.g., drug-resistant subpopulations) to aid personalized vaccine design (e.g … mRNA Velocity-VelomRNARead more