I. Clinical Imperative: PIK3CA as a Therapeutic Biomarker PIK3CA mutations—occurring in 20-40% of breast cancers and up to 30% of colorectal/endometrial cancers—constitutively activate the PI3K/AKT/mTOR pathway, driving tumor progression and therapy resistance. These mutations cluster in helical (ex … PCR-Based Detection of PIK3CA Mutations: Clinical Implementation and Impact in Precision OncologyRead more
Cancer
Practical Applications of CRISPR-Target Technology in Genetic Disease and Cancer Therapy
Practical Applications of CRISPR-Target Technology in Genetic Disease and Cancer Therapy (2025 Update) CRISPR gene editing is revolutionizing the treatment of genetic diseases and cancers through its precision, programmability, and versatility. Below is a systematic analysis of advancements and brea … Practical Applications of CRISPR-Target Technology in Genetic Disease and Cancer TherapyRead more
LNP Vax: Breakthroughs and Clinical Pathways for Lung Cancer Prevention
LNP Vax: Breakthroughs and Clinical Pathways for Lung Cancer Prevention As the leading cause of global cancer mortality, lung cancer prevention has long been constrained by limitations in early screening. The LNP Vax, a lipid nanoparticle (LNP)-based preventive vaccine, is revolutionizing protection … LNP Vax: Breakthroughs and Clinical Pathways for Lung Cancer PreventionRead more
Can Gene Editing Eradicate Cancer? A Multidimensional Analysis
Can Gene Editing Eradicate Cancer? A Multidimensional Analysis Gene editing technologies—particularly CRISPR-Cas9 and its derivatives—show revolutionary potential in cancer treatment. However, whether they can truly “eradicate cancer” requires a comprehensive analysis across three dimens … Can Gene Editing Eradicate Cancer? A Multidimensional AnalysisRead more