Contraindications of COVID-19 Antiviral Therapies: A Comprehensive Analysis (As of May 2025) I. Key Contraindications of Major Antivirals 1. Paxlovid (Nirmatrelvir/Ritonavir) Absolute Contraindications: Hypersensitivity to nirmatrelvir or ritonavir (e.g., Stevens-Johnson syndrome, toxic epidermal ne … Contraindications of COVID-19 Antiviral Therapies: A Comprehensive AnalysisRead more
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Comprehensive Analysis of SARS-CoV-2 Variants and Emerging Treatments
Comprehensive Analysis of SARS-CoV-2 Variants and Emerging Treatments (As of May 2025) I. Key Variants and Epidemiological Features 1. Dominant Circulating Variants XBB.1.5 (“Kraken”): Transmissibility: WHO designates it as the most transmissible Omicron subvariant, with a 3–5x higher R0 … Comprehensive Analysis of SARS-CoV-2 Variants and Emerging TreatmentsRead more
Integrating Viral Vector Technologies with Artificial Intelligence: Key Case Studies
Integrating Viral Vector Technologies with Artificial Intelligence: Key Case Studies (Comprehensive Review as of May 2025) The convergence of viral vector technologies and artificial intelligence (AI) is revolutionizing gene therapy, vaccine development, and precision medicine. By leveraging AI-driv … Integrating Viral Vector Technologies with Artificial Intelligence: Key Case StudiesRead more
Splice Genes in Protein Diversity and Tissue-Specific Regulation: Advances and Applications
Splice Genes in Protein Diversity and Tissue-Specific Regulation: Advances and Applications I. Biological Basis of Alternative Splicing and Protein Diversity 1. Prevalence and Molecular Mechanisms Alternative splicing, a central post-transcriptional regulatory mechanism, generates multiple mRNA isof … Splice Genes in Protein Diversity and Tissue-Specific Regulation: Advances and ApplicationsRead more
Strategies and Recent Advances in Viral Gene-Based Disease Prevention
Strategies and Recent Advances in Viral Gene-Based Disease Prevention The unique biological properties of viral genes—such as high infectivity, target specificity, and programmability—have revolutionized disease prevention. By engineering viral vectors or leveraging viral genome characteristics, sci … Strategies and Recent Advances in Viral Gene-Based Disease PreventionRead more
The Research Significance of Viral Genes in Medical Applications, Gene Therapy, Evolution, and Epidemiology
The Research Significance of Viral Genes in Medical Applications, Gene Therapy, Evolution, and Epidemiology I. Core Roles of Viral Genes in Medical Applications 1. Breakthroughs in Gene Therapy Vectors Genetically engineered viruses serve as efficient gene delivery tools, leveraging their natural in … The Research Significance of Viral Genes in Medical Applications, Gene Therapy, Evolution, and EpidemiologyRead more
SynBio V: Engineering Viral Vectors for mRNA Vaccine Design and Production
SynBio V: Engineering Viral Vectors for mRNA Vaccine Design and Production Integrating Viral Delivery Systems with Synthetic Biology Tools 1. Technological Foundations: Synthetic Biology Reengineering of Viral Vectors Viral vectors, as core mRNA delivery tools, require synthetic biology modification … SynBio V: Engineering Viral Vectors for mRNA Vaccine Design and ProductionRead more
Vector Vaccines: A Cornerstone Tool Against Emerging Infections, Cancer, and Genetic Diseases
Vector Vaccines: A Cornerstone Tool Against Emerging Infections, Cancer, and Genetic Diseases Core Mechanisms and Technical Principles Vector vaccines use engineered viruses or bacteria as delivery vehicles to introduce foreign antigen genes into host cells, triggering specific immune responses. Key … Vector Vaccines: A Cornerstone Tool Against Emerging Infections, Cancer, and Genetic DiseasesRead more