RNA vs. DNA Primers: Complementary Drivers of Molecular Biology As core tools for genetic information transfer and engineering, RNA and DNA primers exhibit complementary molecular mechanisms and applications. Their distinct properties underpin technologies spanning DNA replication to advanced gene e … RNA Primervs. DNA Primers: Complementary Drivers of Molecular BiologyRead more
CRISPR
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a revolutionary gene-editing technology derived from a natural bacterial immune system.
Key points:
Uses a guide RNA to direct the Cas9 protein to cut specific DNA sequences.
Allows precise insertion, deletion, or modification of genes.
Applications: curing genetic diseases, improving crops, biomedical research.
Nobel Prize in Chemistry (2020) awarded to Doudna & Charpentier for its discovery.
It’s faster, cheaper, and more accurate than older gene-editing methods.
Gene Delivery: Cutting-Edge Applications and Future Prospects in Gene Therapy, Vaccine Development, and Basic Research
Gene Delivery: Cutting-Edge Applications and Future Prospects in Gene Therapy, Vaccine Development, and Basic Research Gene delivery technologies are reshaping paradigms in disease treatment, vaccine development, and basic research by enabling precise delivery of nucleic acids or gene-editing tools … Gene Delivery: Cutting-Edge Applications and Future Prospects in Gene Therapy, Vaccine Development, and Basic ResearchRead more
RNAi Tools: Transformative Potential in Genetic Screening, Drug Development, and Precision Medicine
RNAi Tools: Transformative Potential in Genetic Screening, Drug Development, and Precision Medicine Since its discovery in 1998, RNA interference (RNAi) has evolved from a basic research tool into a cornerstone technology driving multidimensional breakthroughs in life sciences. Its innovative applic … RNAi Tools: Transformative Potential in Genetic Screening, Drug Development, and Precision MedicineRead more
BioAI Genome: Ushering in the Programmable Era of Genomics and a Paradigm Shift
BioAI Genome: Ushering in the Programmable Era of Genomics and a Paradigm Shift The “programmable era” of genomics is defined by the deep integration of artificial intelligence (AI) and gene-editing technologies, enabling precise programming and functional redesign of biological systems … BioAI Genome: Ushering in the Programmable Era of Genomics and a Paradigm ShiftRead more
Cross-Species Synthetic Biology and Breakthroughs in Modified RNA Technologies
Cross-Species Synthetic Biology and Breakthroughs in Modified RNA Technologies I. Core Drivers and Prospects of Cross-Species Synthetic Biology Cross-species synthetic biology aims to engineer diverse biological systems (microbes, plants, animals, or artificial cells) to integrate metabolic pathways … Cross-Species Synthetic Biology and Breakthroughs in Modified RNA TechnologiesRead more
Engineered Modified RNA and Its Biological Significance
Engineered Modified RNA and Its Biological Significance Core Technical Strategies for Modified RNA 1. Nucleobase Engineering Natural Modification Engineering: Incorporating naturally occurring modified nucleosides (e.g., N1-methyl-pseudouridine, pseudouridine) into mRNA vaccines reduces immunogenici … Engineered Modified RNA and Its Biological SignificanceRead more
mRNA Velocity in Developmental Biology and Disease Mechanisms: Applications and Prospects (2025 Update)
mRNA Velocity in Developmental Biology and Disease Mechanisms: Applications and Prospects (2025 Update) mRNA Velocity (RNA velocity) is a breakthrough single-cell RNA sequencing (scRNA-seq) technology that infers the directionality and temporal trajectory of cell differentiation by analyzing the dyn … mRNA Velocity in Developmental Biology and Disease Mechanisms: Applications and Prospects (2025 Update)Read more
2025 Global Advances and Applications in AI-Driven Drug Development
2025 Global Advances and Applications in AI-Driven Drug Development AI-driven drug development has entered a critical phase of “scaling from technical validation to industrial application” in 2025, integrating generative AI, multi-omics analysis, quantum computing, and other technologies … 2025 Global Advances and Applications in AI-Driven Drug DevelopmentRead more